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Congenital Diseases and the Environment by A. Mantovani, F. Maranghi (auth.), P. Nicolopoulou-Stamati,

By A. Mantovani, F. Maranghi (auth.), P. Nicolopoulou-Stamati, L. Hens, C.V. Howard (eds.)

In fresh years, expanding recognition and assets were dropped at endure at the dating among the surroundings and congenital illnesses. those ailments have been formerly considered regularly because of genetic reasons. even supposing the significance of genes as elements in causation is authorised, environmental components appear to be implicated simply as strongly. This e-book explores a few additional suggestions that experience arisen from more moderen perceptions of environmental results and their attainable interactions with residing structures. dialogue and presentation of previous and novel principles is concentrated at constructing a extra holistic and united conception of the interplay among congenital illnesses and the environment.

Amongst the subjects mentioned are:

-effects of prenatal publicity to poisonous chemicals

-intra-uterine publicity to medicines

-effects of endocrine disrupters

-environmental chance and intercourse ratio in newborns

-surveillance of environmental impact

-research and policy

This e-book may be of curiosity to researchers in environmental technology and/or human ecology, future health pros, NGOs, and the final public.

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Vorhees, C. , Weisenburger, W. P. and Minck, D. R. (2001) Neurobehavioral teratogenic effects of thalidomide in rats, Neurotoxicol. Teratol. 23, 255-264. H. and Weisglas-Kuprus N. (2002) Effects of perinatal exposure to pcbs and dioxins on play behavior in dutch children at school age, Environ. Health Perspect. 110, A593-A598. Young, A. , Giesy, J. , Jones, P. D. and Newton, M. (2004) Environmental fate and bioavailability of Agent Orange and its associated dioxin during the Vietnam War, Environ.

113, 1056-1061. , Huusom, L. , Hutton, J. L. and Dolk, H. (2004) Multiple birth and cerebral palsy in Europe: a multicenter study", Acta Obstet. Gynecol. Scand. 83, 548-553. Toppari, J. (2003) Physiology and disorders of testicular descent, Endocr. Dev. 5, 104-109. , Kaleva, M. and Virtanen, H. E. (2001) Trends in the incidence of cryptorchidism and hypospadias, and methodological limitations of registry-based data, Hum. Reprod. Update 7, 282-286. Vidaeff, A. C. and Sever, L. E. (2005) In utero exposure to environmental estrogens and male reproductive health: a systematic review of biological and epidemiologic evidence, Reprod.

2000). The use of specific tests, that calculate the variable susceptibility of specific organs and how they develop, by custom-tailoring them to specific maturation markers, will ensure that the action or influence of any potential toxicant can be detected at an early stage (Mantovani and Calamandrei, 2001). , 2004), can prove challenging. The responsibility remains to refine and develop ever more sensitive tests, with better detection in mind, and for specific end points of prenatal exposure.

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