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Clinical Endocrinology and Metabolism (Color Handbook by Pauline Camacho

By Pauline Camacho

This compact but entire consultant to the prognosis and therapy of endocrine and metabolic problems combines the benefits of a brief textual content ebook with these of an atlas, and offers thorough dialogue of every illness supported through a wealth of pictures. each one subject is roofed by means of a expert contributor. whereas reflecting the good advances in biochemical and radiological research, the authors emphasize that analysis of many endocrine stipulations nonetheless will depend on the scientific acumen of physicians.

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ETIOLOGY The primary risk factors for thyroid carcinoma are a family history of thyroid cancer or related genetic syndromes and personal history of radiation exposure. In the 1940s and 1950s, low-dose irradiation was commonly used to treat acne, adenotonsillar hypertrophy, thymus enlargement, and other conditions. As reports of childhood thyroid cancer emerged, the practice was largely abandoned. Any patient with a history of radiation to the face, neck, or chest is at increased risk of developing thyroid neoplasms.

Courtesy of Dr. ) 71 71 Severe ischemic ulceration, (Courtesy of Dr. ) 56 CHAPTER 2 Diabetes mellitus 72 73 73 Radiograph showing osteomyelitis. ) 72 Ulcer with exposed bone and osteomyelitis. (Courtesy of Dr. ) Infection may ultimately lead to osteomyelitis (72, 73). In the context of neuropathy, biomechanical problems, and peripheral vascular disease, a definable precipitating event may start the process of ulceration. This is often poorly fitting footwear. CLINICAL PRESENTATION In its most extreme form, patients with diabetic feet present with foot ulcerations, often infected.

These numbers reflect the explosion of obesity in the US and worldwide. Type 1 diabetes, accounting for about 10% of people with diabetes mellitus, is an autoimmune disease wherein the insulin-producing β cells of the pancreas are destroyed. Treatment relies solely on the use of insulin. Type 2 diabetes mellitus, seen in almost 90% of the diabetic population, has two pathophysiologic loci, insulin resistance and relative or absolute hypoinsulinemia. Insulin resistance, in addition to participating in the development of hyperglycemia, can also lead to hypertriglyceridemia, low levels of high-density lipoprotein (HDL)-cholesterol, hypertension, and truncal obesity and this constellation of features is commonly referred to as the metabolic syndrome.

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