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Clinical Diagnosis and Management of Dystonia by Thomas T. Warner, Susan B. Bressman

By Thomas T. Warner, Susan B. Bressman

Of the typical circulation problems, dystonia may be the main misunderstood and least clinically famous, because the scientific symptoms manifested in sufferers with a variety of dystonic issues are tremendous various. With chapters contributed through specialists from either side of the Atlantic, this textbook presents a entire evaluation of the pathogenesis of dystonia, an outline of the class of a few of the dystonic problems, and a precis of the newest advancements in remedy, together with rising pharmacological treatments and use of botulinum toxin.

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Sample text

4 shows prevalence data, but results should be interpreted with care, as the studies are not prospective or longitudinal, differ considerably in underlying populations, and lack information about the types and dosages of medications given. Dystonia in parkinsonism Age and gender Several studies indicate an association between younger age and higher risk for tardive dystonia,63,67 male preponderance,63,69 and a younger age of onset in men,63 but these studies did not incorporate possible confounders, so the results may be questionable.

1 Unknown Deafness-dystonia syndrome; Mohr–Tranebjaerg syndrome Dystonia, sensorineural deafness, spasticity, mental retardation, female carriers may have adult-onset focal dystonia alone Childhood X-linked with incomplete penetrance, Xq22 Mutations in dystonia-deafness peptide, mitochondrial protein import Leber’s hereditary optic neuropathy plus dystonia Dystonia, optic atrophy, or both Variable Maternal inheritance, mitochondrial DNA NADH dehydrogenase subunit 6, complex 1 These are further described in Chapter 12.

Yassa R, Nair V, Dimitry R. Prevalence of tardive dystonia. Acta Psychiatr Scand 1986; 73: 629–33. 68. Friedman JH, Kucharski LT, Wagner RL. Tardive dystonia in a psychiatric hospital. J Neurol Neurosurg Psychiatry 1987; 50: 801–3. 69. Chiu H, Shum P, Lau J, Lam L, Lee S. Prevalence of tardive dyskinesia, tardive dystonia, and respiratory dyskinesia among Chinese psychiatric patients in Hong Kong. Am J Psychiatry 1992; 149: 1081–5. 70. Raja M. Tardive dystonia, prevalence, risk factors, and comparison with tardive dyskinesia in a population of 200 acute psychiatric inpatients.

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