By Bianca Blom Ph.D. (auth.), Dimitra Anagnostou, Estella Matutes (eds.)
This monograph goals to hide intensive all facets of bone marrow lymphoid infiltrates, within the context in their broad spectrum of benign, borderline and malignant expressions. because the bone marrow isn't any longer thought of a selective diagnostic approach within the box of haematopathology and haematology,but a regimen have to different subspecialists, we intend to supply a finished treatise for rookies and skilled practitioners alike who take care of sufferers which are investigated or taken care of for lymphomas and lymphoid leukemias, show up with laboratory or scientific indicators suspicious for haematological illnesses or convey beneficial properties mimicking haematological conditions.
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Additional info for Bone Marrow Lymphoid Infiltrates: Diagnosis and Clinical Impact
The above results also highlight the intricacies and interactions between various costimulatory proteins that may be critical in the cellular aging of T lymphocytes. For example, ICOS and TLT-2 (the latter found only in murine cells) are other 24 mammalian receptors in T cells that stimulate proliferation, cytokine production, and, in the case of ICOS, survival. ICOS and TLT, therefore, have functions that overlap with CD28 and may, under certain conditions, substitute in for CD28 functions, a scenario likely to take place during T cell activation, since CD28 expression is transiently up- and downregulated after activation .
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