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Blood Coagulation Disorders: Hemorrhagic Diatheses and by Prof. Dr. med. Fritz Reinhard Matthias (auth.)

By Prof. Dr. med. Fritz Reinhard Matthias (auth.)

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These methods are important for the differentiation of rare, mostly congenital defects of 47 platelet function. In this connection, mention should also be made of the determination of the availability of platelet Factor 3. Recently it has become possible to measure the thrombocyte constituents fJ-thromboglobulin and platelet Factor 4 by immunological means on plasma. The concentrations of these provide certain information about thrombocyte activation with release reactions in vivo. A platelet count of less than 30000 per mm3 (normal range between 150000 and 300000 per mm3) is mostly associated with petechial and mucosal hemorrhages.

Hiimostaseologie 1: 13 Ross R, Glomset JA (1976) The pathogenesis of atherosclerosis I. N Engl J Med295: 369 Ross R, Glomset JA (1976) The pathogenesis of atherosclerosis II. N Engl J Med295: 420 Virchow R (1856) Phlogose und Thrombose im GefiiBsystem. Gesammelte Abhandiungen zur wissenschaftlichen Medizin. Frankfurt Wessler S (1975) Factors in the initiations of deep venous thrombosis. In: Nicolaides AN (ed) Thromboembolism - aetiology advances in prevention and management. Medical and Technical Publishing Co Ltd.

The tests of plasmatic system function have the purpose of differentiating the following disorders: 1. Disorders of prothrombin activation in the intrinsic and extrinsic system. 2. Disorders of fibrin formation consequent on coagulation- and fibrinolysis-specific changes in the coagulable substrate. 3. Changes in the inhibitor potential of the coagulation or the fibrinolysis. Both qualitative and quantitative defects may be present. There are numerous immunochemical, physicochemical, chromatographic, and radio isotopic methods available for special diagnostic purposes and for elucidating scientific aspects, but these cannot be discussed in detail here.

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