By Parviz M. Pour M.D., Yoichi Konishi M.D. (auth.), Parviz M. Pour M.D., Yoichi Konishi M.D., Günter Klöppel M.D., Daniel S. Longnecker M.D. (eds.)
The type of tumors is necessary for realizing tumor histogenesis, for predicting analysis, for differential prognosis, and for recommending acceptable remedy. for the reason that 1836, whilst pancreatic melanoma was once first defined, development has been made in pancreatic melanoma morphology, and a couple of classifications were proposed. All of those classifications are commonly according to morphological features. a few are too designated to be of useful use whereas others are extra pragmatic. a number of the inherent difficulties within the earlier classifications integrated problems in acquiring an sufficient variety of pan creatic tumors for exam and inadequate scientific facts and follow-up. With the expanding occurrence of pancreatic melanoma in lots of elements of the area prior to now six many years, and with the supply of extra tumors to patho logists, advances were made in pancreatic tumor reports. Classifications by way of Cubilla and Fitzgerald and by means of Kloppel, that are normally related, often thought of fashionable morphological beneficial properties and their histogenesis. those pathology-oriented classifications, even supposing whole, weren't functional from the point of view of clinicians interested by the diagnosis of person tumors.
Read or Download Atlas of Exocrine Pancreatic Tumors: Morphology, Biology, and Diagnosis with an International Guide for Tumor Classification PDF
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Extra info for Atlas of Exocrine Pancreatic Tumors: Morphology, Biology, and Diagnosis with an International Guide for Tumor Classification
Fine structure of centroacinar cells, which contain a large nucleus (N) and a few organelles. A supranuclear Golgi complex (G) is present. The arrowhead points to interdigitation of adjacent cells. L, Acinar lumen. (X 10000) Fig. 5. Interdigitation of adjacent centroacinar cells (C). The edge of an acinar cell (A) is seen. (X21 000) Fig. 6. Fine structure of the initial part of intercalated ductules. Two of the epithelial cells that comprise the ductule are labeled (IC) . A, Acinar cell; C, centroacinar cell.
H&E, X21O) Immunohistochemistry Fig. 8. a,b. The same tumor as in Figs . 2and 3, a showing abundant cytoplasmic periodic acid Schiff (PAS)-positive granules, b which were completely digested by diastase 37 Serous Cystadenoma Fig. 10. Electron micrograph of the tumor in Fig. 2. The epithelial cells contain intracytoplasmic glycogen granules (x5000) stain with anti-CAI25, anti-CAI9-9 (Fig. Ila), anti-NCC-ST -439 (Fig. II b) and anti-c-erbB-2 antibodies (Fig. Ilc). Serous cystadenoma cells stain only on the apical membrane with antiCA125, anti-CAI9-9, and anti-NCC-ST-439 antibodies.
7c). When an epithelial lining is present, the cells are identical to those seen in the microcystic form. Serous cystadenoma cells of both forms have clear cytoplasm with centrally located nuclei (Fig. 8). Mitotic figures are absent and there is no cytologic atypia. The nucleoli are indistinct and the chromoplasm is finely granular. The epithelial cells of both tumors possess abundant cytoplasmic periodic acid schiff (PAS)-positive granules that can be completely digested by diastase (Fig. 9) .