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Antimicrobial Pharmacodynamics in Theory and Clinical by Charles H. Nightingale, Takeo Murakawa, Paul G. Ambrose

By Charles H. Nightingale, Takeo Murakawa, Paul G. Ambrose (Editors)

This up to the moment reference explores the pharmacodynamics of antimicrobials in addition to the absorption, distribution, metabolism, and removal of the key periods of antimicrobials-covering new brokers similar to ketolide antibiotics and highlighting the pharmacodynamic dating among drug focus and antimicrobial job, in addition to the connection of pharmacodynamics to bacterial resistance. comprises particular examples and functional purposes for the layout of potent dosing regimens! Written by way of well-known specialists within the box, Antimicrobial Pharmacodynamics in conception and medical perform describes ·the pharmacodynamic houses of all significant sessions of antibiotics ·parameters for microbiological job of antimicrobial brokers reminiscent of minimum inhibitory focus (MIC) and minimum bactericidal focus (MBC) ·serum/tissue protein binding and penetration charges ·differences among in vivo and in vitro postantibiotic results (PAE) ·and extra! With approximately one thousand references, tables, drawings, and illustrations, Antimicrobial Pharmacodynamics in idea and medical perform is a state of the art reference for infectious disorder experts, pulmonologists, pharmacists, pharmacologists, microbiologists, organic chemists, epidemiologists, internists, and scholars in those disciplines.

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Extra info for Antimicrobial Pharmacodynamics in Theory and Clinical Practice, 1st Edition (Infectious Disease and Therapy)

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44 Rybak et al. where c c0 ke t ϭ ϭ ϭ ϭ antibiotic concentration concentration following drug administration elimination rate constant time The elimination rate constant is defined by k e ϭ Cl/V c (1) k e ϭ (ln 2)/t 1/2 (2) and Therefore, (ln 2)/t 1/2 ϭ Cl/V c (3) Solving for Cl: Cl ϭ (ln 2)(Vc /t 1/2 ) (4) where Cl ϭ clearance V c ϭ volume in the central compartment t 1/2 ϭ half-life of the drug This system has the advantage of being able to simulate human kinetics by simply utilizing sterile flasks connected by tubing passed through a peristaltic pump.

If one performs a similar analysis with the same or different drug classes against different organisms, a different range of ratios will be found to correlate to acceptable clinical outcomes. This argues that although pharmacodynamic parameters are useful in determining proper dosing, they should be used as a guide rather than as absolute FIGURE 5 Dose–response curve for quinoloones vs. S. pneumoniae. Microbiology and Pharmacokinetics 37 TABLE 3 Oral Quinolone Pharmacodynamics: S. 4 numbers. This concept is further strengthened by the realization that the AUC/ MIC is a ratio with a numerator and a denominator.

Dagan R, Abramason O, Leibovitz E, Greenberg D, Lang R, Goshen S, Yagupsky P, Leiberman A, Fliss DM. Bacteriologic response to oral cephalosporins: Are established susceptibility breakpoints appropriate in the case of acute otitis media? J Infect Dis 1997; 176:1253–1259. 33. Dagan R, Leibovitz E, Fliss DM, Leiberman A, Jacobs MR, Craig W, Yagupsky P. Bacteriologic efficacies of oral azithromycin and oral cefaclor in treatment of acute otitis media in infants and young children. Antimicrob Agents Chemother 2000; 44: 43–50.

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