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Antenatal Diagnosis of Fetal Abnormalities by N. C. Nevin (auth.), James O. Drife MD, FRCSEd, FRCOG, Dian

By N. C. Nevin (auth.), James O. Drife MD, FRCSEd, FRCOG, Dian Donnai MBBS, FRCP, DCH, DObst, RCOG (eds.)

In few parts of drugs is growth extra magnificent than within the box of prenatal prognosis. New scientific strategies resembling chorion villus sampling, exact ultrasound scanning and cordocentesis are being evaluated by means of obstetricians, and refinement of biochemical trying out is widening the scope of maternal serum screening. within the laboratory, dramatic advances in molecular biology are taking place: households liable to genetic illness will be investigated with gene probes, and preimplantation analysis of the embryo is now becom­ ing a fact. those technical advances have vital moral and functional implications, between that allows you to be one more bring up in public expectancies of the criteria required of antenatal prone. Clini­ cians will desire a excessive measure of ability to notify fit ladies concerning the innovations for screening general pregnancies, and to advice high-risk girls concerning the merits and boundaries of prenatal prognosis. Obstetricians, scientists and well-being carrier managers will face the tough job of determining how prenatal prognosis might be made on hand to ladies in a being concerned and reasonable means. Recognising the quick development during this box, the Royal university of Obstetricians and Gynaecologists made prenatal prognosis the topic of its twenty third examine crew. a global panel of prime researchers, whose services ranged from molecular biology to philosophy, was once invited to take part in a 3 day workshop, with time for in-depth dialogue in addition to the presentation of papers.

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Terminations for NTDs would be carried out in any obstetric unit. Second, in terms of prenatal diagnosis, since 1969 we have been running a central genetic obstetric clinic where most of the antenatal screening would be done - ultrasonography, amniocentesis, etc. I am absolutely convinced that this is a true fall and that only a small proportion of that fall is attributable to antenatal screening. Campbell: How much of the fall in prevalence is due to this natural fall and how much to prenatal diagnosis?

6). Others have had a similar experience [8]. 6. 66 Excluding spontaneous abortion. Proportion of all affected pregnancies terminated (%) All mothers Mothers >34 years 16 35 41 86 34 53 The Northern Regional Fetal Abnormality Survey 27 structural chromosome abnormality, rather than just trisomy 21, shows that the total yield from the present policy is higher than a simple review of the birth prevalence of trisomy 21 might suggest. What also comes out of the expanded database available to the regional register is some understanding of why the uptake of selective screening for mothers over 34 years is currently incomplete.

The quality of notification of congenital malformations. J Epidemiol Community Health 1984; 38:296-305. 3. Office of Population Censuses and Surveys. Abortion Statistics 1985-1987. Reports AB12, 13 and 14. London: HMSO, 1986-8. 4. Maxwell DJ, Crawford DC, Curry PVM et al. Obstetric importance, diagnosis and management of fetal tachycardias. Br Med J 1988; 297:107-10. 5. Lenke RR, Hatch EI. Fetal gastroschisis: a preliminary report advocating the use of caesarean section. Obstet Gynecol 1986; 67:395-8.

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