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Additional info for Alzheimer's and Parkinson's Diseases: Progress and New Perspectives: 8th International Conference Ad pd, Salzburg, March 2007: Abstracts (Neuro-Degenerative Diseases)
6 years, MMSE 23. 98% of patients were on L-Dopa. 1 yrs). Agitation, anxiety, irritability and apathy were also noted. 8 years). Conclusions: Visual hallucinations, sleep disturbances, depression and confusion are the most commonly occurring symptoms in this elderly cohort. Average onset of symptoms is about 5 years after diagnosis and appears to be related to the severity of PD. Awareness of these non-motor symptoms and effective management can improve the quality of life for patients with PD.
Josephs, M. M. Pickering-Brown, R. Rademakers, J. M. E. J. C. Petersen 2 Department of Neurology, Robert H. and Clarice Smith and Abigail Van Buren Alzheimer S Disease Research Program, 3 Mayo Clinic, Rochester, MN, Minneapolis Clinic of 4 Neurology, Edina, MN, Department of Neurogenetics, 5 Department of Neuropathology, Mayo Clinic, Jacksonville, 6 FL, Department of Laboratory Medicine and Pathology, 7 Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA ____________________________________ Neurodegenerative Dis 2007;4(suppl 1):1-350 ____________ 33 Background & Aims: We recently identified mutations in progranulin (PGRN) associated with familial frontotemporal dementia and parkinsonism (FTDP).
In June 2005, he suddenly developed bradykinesia, generalized limb muscular rigidity, dysarthria, and dysphasia. 1 mg/dl. ____________ 32 Glucose level was 136 mg/dl and electrolyte levels were with normal limits. T2 weighted MRI images showed extensive hyperintensity over the basal ganglia bilaterally, extending to the adjacent periventricular white matter. On T1 weighted images the lesions was hypointense. Supportive management and hemodialysis were given. His symptoms improved gradually and he recovered after 4 weeks of treatment.