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Advances in Pharmacology, Vol. 35 by J. Thomas August, M.W. Anders, Ferid Murad, Joseph T. Coyle

By J. Thomas August, M.W. Anders, Ferid Murad, Joseph T. Coyle (Eds.)

Each one quantity of Advances in Pharmacology presents a wealthy choice of reports on well timed issues. Emphasis is put on the molecular bases of drug motion, either utilized and experimental.

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H. Drug-food/food-drug interactions. In “Geriatric Nutrition: A Comprehensive Review” Raven Press, NY. Smith, C. , and Bidlack, W. R. Dietary concerns associated with the use of medications. 1. Am. Diet. Assoc. 84, 901. Stiefeld, S. , Graziani, A. , MacGregor, R. , and Esterhai, J. L. (1991). Toxicities of antimicrobial agents used to treat osteomyelitis. Orthop. Clin. North Am. 22, 439. 26 C. Tschanz et al. Thomas, J. , and Tschanz, C. Nutrient-Drug interactions, In “Nutritional Toxicology” (E.

Calcium, iron, magnesium, and zinc can interfere with the GI absorption of tetracyclines. Iron can reduce the absorption of penicillamine (Table XVI). It is evident that a very diverse group of pharmacologic agents can have their actions modified by minerals. Interactions between Drugs and Nutrients 17 E. Genetic Differences Differences in response to drug action among various ethnic and racial subpopulations have long been recognized, and have been accentuated by specific pharmacologic agents causing exaggerated biological reactions.

Diuretic) acting on renal function. Undoubtedly the largest group of agents producing interaction on the GI tract are gastric antacids. , 1984). Antacids are thus capable of interfering with a drug’s absorption. Furthermore, aluminum, which is a constituent of many antacid preparations, can cause a relaxing action on gastric-smooth muscle causing a delay in gastric emptying time. Antacids exert two actions to affect changes in gastric pH and to chelate with minerals to prevent their absorption.

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