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Advances in Molecular and Cellular Endocrinology by Derek Leroith (Eds.)

By Derek Leroith (Eds.)

Quantity 2 has fascinated with points of the pituitary gland either anterior (growth hormone and prolactin receptors, and GH motion) and posterior (vasopressin) pituitary. additionally, thyroid melanoma and steroidogenic enzymes and precocious puberty are lined. eventually, the "hot issues" contain leptin and development issue signaling.

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271, 12991-12998. K. (1995). Prolactin synthesis and secretion by human breast cancer cells. Cancer Res. 55,2591-2595. A. (1992). Alanine-scanning mutagenesis of human prolactin: importance of the 58-74 region for bioactivity. Mol. Endocrinol. 6, 1381-1392. A. (1994). Evidence for a second receptor binding site on human prolactin. J. Biol. Chem. 269, 32598-32606. L. (1995). Use of a model to understand prolactin and growth hormone specificities. Prot. Eng. 8, 1215-1231. A. (1996a). Antagonistic properties of human prolactin analogs that show paradoxical agonistic activity in the Nb2 bioassay.

Although attempts to draw general rules from these data still remain premature, it appears that i) Box 1 is almost an absolute requirement for any PRLR/GHR signaling; ii) receptor tyrosine phosphorylation (by JAK2) is not required for proliferation of all cell types; and iii) in contrast, receptor tyrosine phosphorylation is required for most differentiation signals. However, one must keep in mind first, that results may diverge significantly depending on the cell system used and, second, that data obtained in the particular context of truncated receptors hide the presumed redundancy of some features found in full length receptors, such as the multiplicity of tyrosine residues.

Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase. Cell 74, 237-244. , & Carter-Su, C. (1995). Growth hormone, interferon-g, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1. J. Biol. Chem. 270, 14685-14692. M. (1994). Raf meets Ras: completing the framework of a signal transduction pathway. TIBS 19, 279-283. A. (1991). A systematic mutational analysis of hormone-binding determinants in the human growth hormone receptor.

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