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A Practical Guide to Diabetes Mellitus by Nihal, Thomas; Nitin, Kapoor, Jachin Velavan, Senthil Vasan,

By Nihal, Thomas; Nitin, Kapoor, Jachin Velavan, Senthil Vasan,

A pragmatic advisor to Diabetes Mellitus is the newest variation of this complete, hugely illustrated advisor to diabetes. The e-book is made from 30 chapters, encompassing a number useful remedies for diabetes. starting with an summary of the anatomy and body structure of the pancreas, next chapters disguise themes akin to clinical meals treatment, insulin treatment, diabetic foot, and ocular disorder. This version contains fresh chapters on weight problems, wound care, the aged and epidemiology. The bankruptcy on insulin remedy outlines key elements of insulin injection innovations, blending of insulin, and websites for insulin management. This revised and greater variation of a pragmatic advisor to Diabetes Mellitus is more advantageous through 136 complete color photographs and illustrations, making it an awesome better half for all scholars and practitioners of diabetology, and basic physicians. Key issues * most up-to-date variation of finished advisor to diabetes * prior variation released 2012 (9789350259672) * New chapters on weight problems, wound care, the aged, and epidemiology *136 complete color photographs and illustrations

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However, symptoms like angina and transient ischemic attacks are often pointers of more fatal complications in future, which may be preventable. Peripheral vascular disease should be evaluated by symptoms of claudication. These should differentiate from symptoms of neuropathic pain as covered in the chapter of diabetic foot. A detailed history of autonomic symptoms is also important, as they often hinder day to day normal functioning and require appropriate management. To know past history of infective complications in patients with diabetes is also of para­ mount importance, as urinary tract and lower respiratory tract infections are the leading cause of death in developing countries in these individuals.

27 28 A Practical Guide to Diabetes Mellitus It is also vital to find out the frequency and method of glucose monitoring and the type of control achieved over the past few months, in all patients with diabetes. This apart from glycemic control also displays patients’ attitude, knowledge and seriousness towards the disease. All patients should be explored for probable hypoglycemic episodes that they may have experienced in the past. If so, we should further probe on the timing, precipitating event and recovery measures taken, to avoid further such episodes.

Studies have shown that acute administration of GLP-1 induces satiety and decreases calorie intake. In humans with type 2 diabetes, short-term GLP-1 or exendin-4 administration curbs appetite and food intake in addition to its insulinotropic actions, Physiology suggesting in long-term; this will promote weight loss in these patients. The ability of GLP-1 analogs to promote weight loss and improve b cell function has made these agents useful for the treatment of type 2 diabetes. Properties and Biological Actions of GIP and GLP-1 In a nutshell, antidiabetic potential of GLP-1 is mediated by the following mechanisms: • Glucose-dependent insulinotropic actions; • Glucagonostatic actions; • A reduction in appetite/promotion of satiety leading to reduced food intake and weight reduction; • The deceleration of gastric emptying; and • The stimulation of islet growth, differentiation and regeneration.

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