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A Multidisciplinary Approach to Myelin Diseases II by K. Kitagawa, D. R. Colman (auth.), S. Salvati (eds.)

By K. Kitagawa, D. R. Colman (auth.), S. Salvati (eds.)

The ailments that fall below the generalized crew of demyelinating illnesses -Multiple Sclerosis, Leukodystrophyes, Encephalomyelitis-are the point of interest of globally crisis. This quantity comprises papers offered by way of prime scientists who attended the NATO complex examine Workshop held on the Istituto Superiore di SanitA, Rome, March 1-4, 1993. This publication is an replace of the former one released in 1987 of the examine mentioned at an analogous assembly held in 1986. It was once determined to carry this 2d assembly in view that there was nice growth within the advances in realizing the myelinogenesis technique within the final 5 years. The workshop amassed jointly scientists from many fields akin to mobile and molecular biology, immunology, pathology, virology and naturally scientific neurology. Stimulating rules have been exchanged within the desire that extra wisdom of demyelinating illnesses may end up in new theraupetic methods. even though the workshop was once mainly just like the former one, this time there has been extra emphasis on experimental types and medical facets. within the former using animal and mobile types as instruments for knowing the pathological mechanisms associated with human illness have been mentioned; within the latter the clinicians defined the filtering down of uncomplicated learn to scientific remedy The e-book of this interdisciplinary alternate is to make recognized the result of the latest study one of the investigators from allover the realm concerned about those studies.

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Evidence for this mode of transport was first presented by Colman and collaborators (1982), who showed a 20fold enrichment of MBP mRNA in RNA extracts of purified myelin fractions when compared to RNA extracts of whole brain homogenate. Based on this observation, they proposed that the majority of MBP synthesis occurs along the myelin internode on polysomes that are present in the outer tongue process. , 1989). , 1988). It is apparent, therefore, that only a subpopulation of the total mRNAs encoding peripheral membrane proteins has a signal for transport out along the myelin internode.

And Mikoshiba, K. Core promoter of the mouse myelin basic protein gene governs brain-specific transcription in vitro. Embo J. 9:3101-3108 (1990). 10. , and Khalili, K. Analysis of the proximal transcriptional element of the myelin basic protein gene. Res. 20:545-550 (1992). 11. , Okano, H. Tissue-specific in vitro transcription from the mouse myelin basic protein promoter. Mol. Cell. BioI. 9:3122-3126 (1989). 12. , and Mikoshiba, K. Detection of brain-specific gene expression in brain cells in primary culture: a novel promoter assay based on the use of a retrovirus vector.

OO55) and ARSEP to BZ and Association Fran~aise contre les Myopathies to Ch. B. 27 REFERENCES 1. A. Emergence of three myelin proteins in oligodendrocytes cultured without neurons. J. , 102:384-392 (1986). 2. , and Zalc, B. Oligodendroglia! expression and deposition of four major myelin constituents in the myelin sheath during development: an in vivo study. Dev. Neurosci. 8:222-235 (1986). 3. 4. 5. 6. 7. W. Proteins of myelin. In: Myelin, P. ) Plenum Press, New York, pp. 197-224 (1984). , and Hood, L.

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